Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376928 | 0.91 | PDE10A (0.46) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9700065 | 0.86 | PDE10A (0.44) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9698911 | 0.84 | PDE10A (0.41) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL7352500 | 0.82 | PDE10A (0.51) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9198832 | 0.82 | PDE10A (0.42) | PDE10ATGFBR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7378903 | 0.81 | PDE10A (0.41) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9700106 | 0.79 | PDE10A (0.47) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9198377 | 0.78 | PDE10A (0.45) | PDE10ATGFBR1GABRA1GABRG2GABRB3 | |
| SCHEMBL9698891 | 0.77 | POLB (0.44) | PDE10ATGFBR1NPC1RAB9AKDM4E | |
| SCHEMBL9204502 | 0.75 | PDE10A (0.43) | PDE10ATGFBR1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | claimed |
| EP-0411754-A2 | Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-06 | — | — | EP | disclosed |
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |