Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361293 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| SCHEMBL7381786 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| Hydrochloric Acid SCHEMBL9658987 | 0.98 | CHRNB4 (0.54) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| Hydrochloric Acid SCHEMBL9658991 | 0.98 | CHRNB4 (0.54) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| Hexane SCHEMBL7381907 | 0.93 | CHRNB4 (0.50) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| SCHEMBL27870139 | 0.87 | CHRNB4 (0.49) | CHRNB4CHRNA3KDM4EPDE4BCA2 | |
| SCHEMBL27516106 | 0.87 | CHRNB4 (0.55) | CHRNB4CHRNA3KDM4E | |
| SCHEMBL14683211 | 0.87 | CHRNB4 (0.49) | CHRNB4CHRNA3HTR6POLB | |
| SCHEMBL9853143 | 0.87 | GAA (0.51) | CHRNB4CHRNA3KDM4EPDE4BHTR6 | |
| SCHEMBL9852941 | 0.82 | SMN1; SMN2 (0.46) | CHRNB4CHRNA3HTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426075-A1 | Benzylpyrrolidine derivatives as dopamine agonists | SYNTEX (U.S.A.) INC. (US) | 1991-05-08 | — | — | EP | disclosed |
| EP-0404115-A1 | Bis(benzylpyrrolidine)Derivatives as dopamine agonists | SYNTEX (U.S.A.) INC. (US) | 1990-12-27 | — | — | EP | disclosed |