Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381350 | 0.88 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7380119 | 0.88 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSSTR5 | |
| SCHEMBL196243 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29623586 | 0.87 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7379042 | 0.87 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DSSTR5 | |
| Hydrochloric Acid SCHEMBL30543740 | 0.86 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL154624 | 0.86 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7381816 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7384774 | 0.85 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7205525 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | disclosed |