⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592665 | 0.58 | — | — | |
| SCHEMBL6973662 | 0.57 | — | — | |
| SCHEMBL10536753 | 0.56 | — | — | |
| SCHEMBL2013523 | 0.56 | — | — | |
| SCHEMBL498103 | 0.56 | — | — | |
| SCHEMBL10187693 | 0.54 | — | — | |
| Hydrogen Sulfide SCHEMBL29012697 | 0.53 | — | — | |
| SCHEMBL7426229 | 0.52 | — | — | |
| SCHEMBL19920717 | 0.50 | — | — | |
| SCHEMBL20504484 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294601-B1 | TRANSDERMAL DELIVERY OF PHARMACEUTICALS | AMERICAN CYANAMID COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| US-5160734-A | Complex with polyoxyethylene-polyoxypropylene copolymer | AMERICAN CYANAMID COMPANY (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0317780-B1 | SUSTAINED (CONTROLLED) RELEASE DELIVERY SYSTEM FOR SUBSTITUTED DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS | AMERICAN CYANAMID COMPANY (US) | 1992-05-20 | — | — | EP | disclosed |
| US-5114946-A | An enantiomorphs and a vehicle for drug deliversy | AMERICAN CYANAMID COMPANY (US) | 1992-05-19 | — | — | US | disclosed |
| US-5001139-A | Enchancers for the transdermal flux of nivadipine | AMERICAN CYANAMID COMPANY (US) | 1991-03-19 | — | — | US | disclosed |
| US-4992445-A | Enantiomorphs of active chiral compounds in vehicle | AMERICAN CYANAMID CO. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0321636-A2 | Enhancers for the transdermal flux of certain 1,4-Dihydropyridine derivatives | AMERICAN CYANAMID COMPANY (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0317780-A1 | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers | AMERICAN CYANAMID COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0294601-A2 | Transdermal delivery of pharmaceuticals | AMERICAN CYANAMID COMPANY (US) | 1988-12-14 | — | — | EP | disclosed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |