Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.64 |
| ▸ | PDE4A | P27815 | 10/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358441 | 0.84 | PDE4D (0.72) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL984917 | 0.83 | PDE4D (0.57) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157750 | 0.82 | EPHA2 (0.62) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157459 | 0.81 | POLB (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157647 | 0.81 | POLB (0.57) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7421935 | 0.81 | PDE4D (0.67) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157480 | 0.80 | PDE4A (0.57) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157448 | 0.80 | POLB (0.56) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157875 | 0.79 | PDE4D (0.64) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL1157770 | 0.79 | POLB (0.53) | PDE4BPDE4DPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |