Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380774 | 0.86 | ACE (0.59) | ACEALDH1A1ACE2KMT2A | |
| SCHEMBL11154974 | 0.81 | ACE (0.64) | ACEKLK5ALDH1A1ACE2DPP4 | |
| SCHEMBL11448839 | 0.79 | POLB (0.48) | ACEKLK5ALDH1A1ALOX5FKBP1A | |
| SCHEMBL1762519 | 0.79 | KMT2A (0.59) | ACEALDH1A1ALOX5KMT2A | |
| SCHEMBL9871506 | 0.79 | KMT2A (0.59) | ACEALDH1A1ALOX5KMT2A | |
| SCHEMBL24435015 | 0.79 | KMT2A (0.59) | ACEALDH1A1ALOX5KMT2A | |
| SCHEMBL10509005 | 0.79 | ACE (0.59) | ACEKLK5ALDH1A1ALOX5FKBP1A | |
| SCHEMBL6639156 | 0.79 | ACE (0.59) | ACEKLK5ALDH1A1ALOX5FKBP1A | |
| SCHEMBL10508467 | 0.77 | ACE (0.62) | ACEKLK5ALDH1A1FKBP1A | |
| SCHEMBL10508472 | 0.77 | ACE (0.62) | ACEKLK5ALDH1A1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833152-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1989-05-23 | — | — | US | disclosed |
| US-4745124-A | THIO/ESTER PEPTIDES | UNIVERSITY OF MIAMI (US) | 1988-05-17 | — | — | US | disclosed |
| US-4734420-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | UNIVERSITY OF MIAMI (US) | 1988-03-29 | — | — | US | disclosed |
| US-4692458-A | Anti-hypertensive agents | UNIVERSITY OF MIAMI (US) | 1987-09-08 | — | — | US | disclosed |
| US-4690936-A | AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0036713-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | UNIVERSITY OF MIAMI (US) | 1984-01-18 | — | — | EP | disclosed |
| EP-0036713-A2 | Angiotensin converting enzyme inhibitors | UNIVERSITY OF MIAMI (US) | 1981-09-30 | — | — | EP | disclosed |
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |