Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 11/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | PGR | P06401 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7378569 | 0.96 | CACNA1C (0.70) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Fumaric Acid SCHEMBL7378572 | 0.96 | CACNA1C (0.70) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7379491 | 0.92 | CACNA1C (0.78) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8215921 | 0.91 | CACNA1C (0.89) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7381028 | 0.91 | CYP1A2 (0.78) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9808244 | 0.91 | CACNA1C (0.77) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10387008 | 0.89 | CYP1A2 (0.84) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Nicardipine SCHEMBL29190306 | 0.89 | CYP1A2 (0.91) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Nicardipine SCHEMBL1523512 | 0.88 | CACNA1C (0.95) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10388022 | 0.88 | CYP1A2 (0.84) | CACNA1CCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |