Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.49 |
| ▸ | PDE4A | P27815 | 19/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675072 | 0.88 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388089 | 0.85 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1918433 | 0.84 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6154633 | 0.84 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL30074724 | 0.84 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7205215 | 0.83 | PDE4A (0.57) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7210441 | 0.82 | PDE4A (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7381568 | 0.82 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7858949 | 0.81 | PDE4A (0.48) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7379736 | 0.80 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541078-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | claimed |
| CN-1377353-A | Purine derivatives having phosphodiesterase IN inhibition activity | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | CN | claimed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | claimed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | claimed |
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| CN-1377353-A | Purine derivatives having phosphodiesterase IN inhibition activity | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | CN | disclosed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | disclosed |
| US-6319928-B1 | ASTHMA, ALLERGIES, INFLAMMATION,DEPRESSION, DEMENTIA, ALZHEIMER'S DISEASE, VASCULAR AND MULTI-IN-FARCT DEMENTIA AND DISEASE CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS TREATMENT; EFFICIENCY AND SELECTIVITY | EURO-CELTIQUE, S.A. (LU) | 2001-11-20 | — | — | US | disclosed |
| US-6294541-B1 | ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES | EURO-CELTIQUE S.A. (LU) | 2001-09-25 | — | — | US | disclosed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | disclosed |