SCHEMBL7380914

SCHEMBL7380914

CC(=O)SCC(C)C(=O)N1CCCCC1C(=O)O

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACE P12821 7/20 0.59
REN P00797 4/20 0.59
KDM4E B2RXH2 1/20 0.59
F2 P00734 1/20 0.59
LMNA P02545 1/20 0.59
LTA4H P09960 1/20 0.59
MAPT P10636 1/20 0.59
PEPD P12955 1/20 0.59
ALOX15 P16050 1/20 0.59
PTGS1 P23219 1/20 0.59
HTR2A P28223 1/20 0.59
PTGS2 P35354 1/20 0.59
HRH1 P35367 1/20 0.59
THPO P40225 1/20 0.59
PMP22 Q01453 1/20 0.59
HSD17B10 Q99714 1/20 0.59
ACE2 Q9BYF1 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3629351 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL8014055 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL6788422 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL4763848 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL6786845 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL6788431 0.96 ACE (0.65) ACERENKDM4EF2LMNA
SCHEMBL10794601 0.91 ACE (0.59) ACERENKDM4EF2LMNA
SCHEMBL10794593 0.91 ACE (0.59) ACERENKDM4EF2LMNA
SCHEMBL7379018 0.90 ACE (0.56) ACERENKDM4EF2LMNA
SCHEMBL11438761 0.87 ACE (0.50) ACERENKDM4EF2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4833152-A Anti-hypertensive agents UNIVERSITY OF MIAMI (US) 1989-05-23 US disclosed
US-4745124-A THIO/ESTER PEPTIDES UNIVERSITY OF MIAMI (US) 1988-05-17 US disclosed
US-4734420-A INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME UNIVERSITY OF MIAMI (US) 1988-03-29 US disclosed
US-4692458-A Anti-hypertensive agents UNIVERSITY OF MIAMI (US) 1987-09-08 US disclosed
US-4690936-A AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS UNIVERSITY OF MIAMI (US) 1987-09-01 US disclosed
EP-0036713-B1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS UNIVERSITY OF MIAMI (US) 1984-01-18 EP disclosed
EP-0036713-A2 Angiotensin converting enzyme inhibitors UNIVERSITY OF MIAMI (US) 1981-09-30 EP disclosed
US-4154840-A Antihypertensive pipecolic acid derivatives E. R. SQUIBB & SONS, INC. (US) 1979-05-15 US disclosed
US-4105776-A ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1978-08-08 US disclosed
US-4046889-A HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION E. R. SQUIBB & SONS, INC. (US) 1977-09-06 US disclosed