Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11282285 | 0.96 | ACE (0.49) | ACEKMT2A | |
| SCHEMBL10943170 | 0.88 | ACE (0.43) | ACEKMT2A | |
| SCHEMBL7373250 | 0.86 | KLK5 (0.45) | ACE | |
| SCHEMBL10954711 | 0.86 | ACE (0.62) | ACEKMT2AACE2 | |
| SCHEMBL10508293 | 0.86 | ACE (0.62) | ACEKMT2AACE2 | |
| SCHEMBL7378528 | 0.86 | ACE (0.62) | ACEKMT2AACE2 | |
| SCHEMBL11549184 | 0.84 | KLK5 (0.47) | ACEACE2 | |
| SCHEMBL11546123 | 0.84 | KLK5 (0.42) | ACEACE2 | |
| SCHEMBL11387102 | 0.83 | KLK5 (0.47) | ACEACE2 | |
| SCHEMBL11387234 | 0.83 | KLK5 (0.47) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |
| US-4046889-A | HYPOTENSIVE AGENTS, ENZYME INHIBITORS, ANGIOTENSIN CONVERSION | E. R. SQUIBB & SONS, INC. (US) | 1977-09-06 | — | — | US | disclosed |