Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179932 | 0.87 | FOLH1 (0.52) | FOLH1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL18112961 | 0.83 | HTT (0.46) | FOLH1SMN1; SMN2HTTCYP2C19CTSB | |
| SCHEMBL27507026 | 0.82 | HTT (0.44) | FOLH1SMN1; SMN2HTTCYP2C19CTSB | |
| SCHEMBL28515540 | 0.81 | TSHR (0.45) | SMN1; SMN2HTTCYP2C19CTSB | |
| SCHEMBL291194 | 0.81 | SMN1; SMN2 (0.57) | FOLH1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL712393 | 0.79 | MAPT (0.56) | FOLH1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL25118449 | 0.79 | CETP (0.43) | MAPK1 | |
| SCHEMBL7382506 | 0.79 | HPGD (0.52) | MAPK1LTA4H | |
| SCHEMBL2867823 | 0.78 | MAPT (0.59) | FOLH1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL22367410 | 0.78 | SMN1; SMN2 (0.53) | FOLH1SMN1; SMN2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192125-A2 | MONO- AND DISUBSTITUTED 3-PROPYL GAMMA-AMINOBUTYRIC ACIDS | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076958-A2 | MONO- AND DISUBSTITUTED 3-PROPYL GAMMA-AMINOBUTYRIC ACIDS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |