⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17093435 | 0.77 | MAOB (0.38) | — | |
| SCHEMBL1149178 | 0.74 | — | — | |
| SCHEMBL1245328 | 0.74 | — | — | |
| SCHEMBL19069487 | 0.72 | MAOB (0.34) | — | |
| SCHEMBL21235970 | 0.70 | MAOB (0.37) | — | |
| SCHEMBL22917063 | 0.70 | CHRM1 (0.37) | — | |
| SCHEMBL3020647 | 0.68 | — | — | |
| SCHEMBL24584917 | 0.68 | MAOB (0.32) | — | |
| SCHEMBL19177048 | 0.68 | MAOB (0.32) | — | |
| SCHEMBL17093436 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573498-B1 | ALIPHATIC PROPARGYLAMINES AS SELECTIVE MAO-B INHIBITORS AND AS NEUROPROTECTIVE AGENTS | UNIV SASKATCHEWAN (CA) | 1998-11-18 | — | — | EP | disclosed |
| US-5508311-A | Aliphatic propargylamines as selective MAO-B inhibitors and as neuroprotective agents | UNIVERSITY OF SASKATCHEWAN (CA) | 1996-04-16 | — | — | US | disclosed |
| EP-0573498-A1 | ALIPHATIC PROPARGYLAMINES AS SELECTIVE MAO-B INHIBITORS AND AS NEUROPROTECTIVE AGENTS | UNIVERSITY OF SASKATCHEWAN (CA) | 1993-12-15 | — | — | EP | disclosed |
| US-5169868-A | Antidepressants, enzyme inhibitors; alleviating parkinsonism, alzheimer's disease | UNIVERSITY OF SASKATCHEWAN (CA) | 1992-12-08 | — | — | US | disclosed |
| WO-1992015551-A1 | ALIPHATIC PROPARGYLAMINES AS SELECTIVE MAO-B INHIBITORS AND AS NEUROPROTECTIVE AGENTS | UNIVERSITY OF SASKATCHEWAN (CA) | 1992-09-17 | — | — | WO | disclosed |