Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375020 | 0.86 | CYP11B1 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL3715232 | 0.86 | CYP11B1 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL7374943 | 0.85 | CYP11B1 (0.39) | ALDH1A1KDM4ELMNACYP2C19CYP11B1 | |
| SCHEMBL7382224 | 0.85 | CYP11B1 (0.41) | LMNACYP11B1CYP11B2 | |
| SCHEMBL7379194 | 0.84 | ACE2 (0.42) | CYP11B1CYP11B2 | |
| SCHEMBL7398066 | 0.84 | CYP11B1 (0.37) | ALDH1A1KDM4ETDP1CYP11B1CYP11B2 | |
| SCHEMBL7384484 | 0.82 | CYP11B1 (0.41) | ALDH1A1KDM4ELMNATDP1POLB | |
| SCHEMBL7383285 | 0.82 | ACE2 (0.38) | CYP11B1CYP11B2 | |
| SCHEMBL3686724 | 0.82 | CYP11B1 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL1655292 | 0.81 | CYP11B1 (0.36) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| EP-1183019-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000066104-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |