Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655482 | 0.94 | ACE2 (0.59) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL1655470 | 0.94 | ACE2 (0.59) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL3715181 | 0.94 | ACE2 (0.43) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL7427916 | 0.91 | ACE2 (0.70) | ACE2ACECYP11B1CYP11B2P2RX3 | |
| SCHEMBL1656651 | 0.90 | CYP11B1 (0.52) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL7382789 | 0.88 | ACE2 (0.46) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL3681437 | 0.87 | ACE2 (0.48) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL7391521 | 0.87 | ACE2 (0.45) | ACE2ACECYP11B1CYP11B2NR3C1 | |
| SCHEMBL7531327 | 0.86 | ACE2 (0.52) | ACE2ACECYP11B1CYP11B2FNTA | |
| SCHEMBL1655465 | 0.86 | ACE2 (0.45) | ACE2ACECYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543120-A | — | — | 2002-12-17 | — | — | JP | claimed |
| WO-2000066104-A9 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARM INC (US) | 2002-08-29 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| EP-1183019-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2002-03-06 | — | — | EP | claimed |
| WO-2000066104-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | claimed |