Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.60 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696582 | 0.93 | — | — | |
| SCHEMBL2051058 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL2046192 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL1925780 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL11513220 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL7777818 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL2047984 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL11407439 | 0.89 | TRIM24 (0.71) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| Hydrochloric Acid SCHEMBL31406581 | 0.86 | TRIM24 (0.67) | TRIM24TRIM33ALDH1A1CYP2A6CA1 | |
| SCHEMBL106541 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096887-A | USEFUL IN THE DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND FOR ENHANCEMENT OF MEMORY. | NEUROGEN CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| US-5925770-A | GAMMA-AMINOBUTYRIC ACID DERIVATIVES FOR DIAGNOSIS OR TREATMENT OF ANXIETY, SLEEP DISORDERS, SEIZURES, OVERDOSES OF BENZODIAZEPINE TYPE DRUGS, COGNITION ACTIVATORS | NEUROGEN CORPORATION (US) | 1999-07-20 | — | — | US | disclosed |
| US-5750702-A | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| US-5723462-A | SLEEP AND SEIZURE DISORDERS; COGNITION ACTIVATORS, ANXIOLYTIC AGENTS | NEUROGEN CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |