Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385281 | 1.00 | CACNA1B (0.55) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7392894 | 0.86 | CACNA1B (0.54) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7394739 | 0.83 | CACNA1B (0.61) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7394742 | 0.83 | CACNA1B (0.61) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7393942 | 0.82 | CACNA1B (0.70) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7391849 | 0.82 | CACNA1B (0.52) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7661290 | 0.78 | CACNA1B (0.53) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7392896 | 0.78 | CACNA1B (0.53) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7382706 | 0.78 | CACNA1B (0.58) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 | |
| SCHEMBL7382703 | 0.78 | CACNA1B (0.58) | CACNA1BRAB9AFAAHCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | claimed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | claimed |
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |