Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.69 |
| ▸ | MME | P08473 | 3/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338396 | 0.90 | ACE (0.71) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7443809 | 0.90 | ACE (0.71) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7338418 | 0.90 | ACE (0.71) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7338402 | 0.90 | ACE (0.71) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7346617 | 0.82 | ACE (1.00) | ACEMMEHRH4 | |
| SCHEMBL7436098 | 0.82 | ACE (1.00) | ACEMMEHRH4 | |
| SCHEMBL7346611 | 0.82 | ACE (1.00) | ACEMMEHRH4 | |
| SCHEMBL7346605 | 0.82 | ACE (1.00) | ACEMMEHRH4 | |
| SCHEMBL7344771 | 0.81 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7344775 | 0.81 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750631-B1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO(C)AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMA INC (US) | 2000-04-05 | — | — | EP | disclosed |
| EP-0750631-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO(C)AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-02 | — | — | EP | disclosed |
| WO-1995021854-A1 | NOVEL MERCAPTOACETYLAMIDO 1,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-3-ONE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |