Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313636 | 0.98 | KMT2A (0.72) | KMT2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7539835 | 0.97 | KMT2A (0.74) | KMT2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL1007128 | 0.93 | KMT2A (0.78) | KMT2AALDH1A1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL23778358 | 0.88 | KMT2A (0.70) | KMT2AALDH1A1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5470264 | 0.86 | KMT2A (0.61) | KMT2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL1625323 | 0.86 | KMT2A (0.68) | KMT2ASLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL4878379 | 0.86 | KMT2A (0.68) | KMT2ASLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL2288239 | 0.85 | KMT2A (0.67) | KMT2AALDH1A1KDM1A | |
| Hydrochloric Acid SCHEMBL3249332 | 0.85 | KMT2A (0.67) | KMT2ASLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL11814914 | 0.85 | KMT2A (1.00) | KMT2ASLC6A4SLC6A2SLC6A3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223530-A | Selective high-affinity ligands for treatment of psychological disorders, side effect reduction | SRI, INTERNATIONAL (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0495084-A1 | ARYLCYCLOALKANEPOLYALKYLAMINES | SRI INTERNATIONAL (US) | 1992-07-22 | — | — | EP | disclosed |
| WO-1992002481-A1 | ARYLCYCLOALKANEPOLYALKYLAMINES | SRI INTERNATIONAL (US) | 1992-02-20 | — | — | WO | disclosed |
| US-5086054-A | Selective high-affinity ligands to sigma boding sites, administering, amipsychotic, antiarrhythmia, antiischemic agents anticonvulsants, reduced side effects | SRI INTERNATIONAL (US) | 1992-02-04 | — | — | US | disclosed |