Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738811 | 1.00 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL762668 | 0.93 | HRH1 (0.46) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL740472 | 0.87 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL741026 | 0.87 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL740935 | 0.86 | HRH1 (0.44) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL762666 | 0.86 | KCNH2 (0.40) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL741047 | 0.85 | HRH1 (0.50) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL739699 | 0.85 | HRH1 (0.50) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL741010 | 0.85 | HRH1 (0.50) | KCNH2HRH1CYP2D6CHRM1USP2 | |
| SCHEMBL741011 | 0.85 | HRH1 (0.50) | KCNH2HRH1CYP2D6CHRM1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |