Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 17/20 | 0.61 |
| ▸ | CNR1 | P21554 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122540 | 0.89 | CNR2 (0.64) | CNR2CNR1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL735768 | 0.82 | CNR2 (0.62) | CNR2CNR1 | |
| SCHEMBL13588573 | 0.79 | CNR2 (0.72) | CNR2CNR1 | |
| SCHEMBL740358 | 0.76 | CNR2 (0.62) | CNR2CNR1MEN1KMT2A | |
| SCHEMBL740432 | 0.76 | CNR2 (0.66) | CNR2CNR1 | |
| SCHEMBL740431 | 0.76 | CNR2 (0.66) | CNR2CNR1 | |
| SCHEMBL739583 | 0.76 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL737821 | 0.76 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL737657 | 0.74 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL737775 | 0.74 | CNR2 (0.74) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138177-B2 | Benzimidazolone derivatives as CB2 receptor ligands | PFIZER INC. (US) | 2012-03-20 | — | — | US | claimed |
| EP-1861377-B1 | BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS | PFIZER (US) | 2010-12-29 | — | — | EP | disclosed |