Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.81 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.81 |
| ▸ | TNF | P01375 | 1/20 | 0.81 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230002 | 0.90 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL31357411 | 0.90 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL13907295 | 0.85 | CYP11B1 (0.89) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL27839811 | 0.84 | CYP11B1 (0.87) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL27699770 | 0.84 | CYP11B1 (0.87) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL28610944 | 0.83 | CYP11B1 (0.84) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL9049676 | 0.81 | CYP11B1 (1.00) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL31722842 | 0.80 | CYP11B1 (0.80) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| SCHEMBL3177643 | 0.80 | CYP11B1 (0.80) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 | |
| Pyrene SCHEMBL28304362 | 0.79 | CYP11B1 (0.77) | CYP11B1CYP11B2TNFHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628549-B1 | New 1-phenylmethyl benzimidazole piperazine derivatives | ESPANOLA DE PRODUCTOS FAB (ES) | 2000-12-06 | — | — | EP | claimed |
| EP-0628549-A1 | New 1-phenylmethyl benzimidazole piperazine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1994-12-14 | — | — | EP | claimed |
| EP-0628549-B1 | New 1-phenylmethyl benzimidazole piperazine derivatives | ESPANOLA DE PRODUCTOS FAB (ES) | 2000-12-06 | — | — | EP | disclosed |
| EP-0628549-B1 | New 1-phenylmethyl benzimidazole piperazine derivatives | ESPANOLA DE PRODUCTOS FAB (ES) | 2000-12-06 | — | — | EP | disclosed |
| US-5672604-A | SEROTONIN RECEPTOR ANTAGONISTS | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS (FAES) (ES) | 1997-09-30 | — | — | US | disclosed |
| US-5672604-A | SEROTONIN RECEPTOR ANTAGONISTS | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS (FAES) (ES) | 1997-09-30 | — | — | US | disclosed |
| US-5672604-A | SEROTONIN RECEPTOR ANTAGONISTS | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS (FAES) (ES) | 1997-09-30 | — | — | US | disclosed |
| EP-0628549-A1 | New 1-phenylmethyl benzimidazole piperazine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628549-A1 | New 1-phenylmethyl benzimidazole piperazine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628549-A1 | New 1-phenylmethyl benzimidazole piperazine derivatives | FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. (FAES) (ES) | 1994-12-14 | — | — | EP | disclosed |