Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.84 |
| ▸ | CSF1R | P07333 | 10/20 | 0.84 |
| ▸ | FLT3 | P36888 | 4/20 | 0.84 |
| ▸ | KIT | P10721 | 3/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.84 |
| ▸ | PIM1 | P11309 | 5/20 | 0.56 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731839 | 1.00 | KDR (0.84) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL731838 | 1.00 | KDR (0.84) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL10151247 | 1.00 | KDR (0.84) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL731840 | 1.00 | KDR (0.84) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729114 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729265 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729113 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729584 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL729115 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 | |
| SCHEMBL738436 | 0.92 | KDR (1.00) | KDRCSF1RFLT3KITCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138181-B2 | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2012-03-20 | — | — | US | disclosed |