Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.62 |
| ▸ | PDE6D | O43924 | 3/20 | 0.47 |
| ▸ | PDE6A | P16499 | 3/20 | 0.47 |
| ▸ | PDE6G | P18545 | 3/20 | 0.47 |
| ▸ | PDE6B | P35913 | 3/20 | 0.47 |
| ▸ | PDE6C | P51160 | 3/20 | 0.47 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4987622 | 0.90 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7167145 | 0.84 | PDE5A (0.54) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4991681 | 0.83 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7167645 | 0.81 | PDE5A (0.51) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4989485 | 0.81 | PDE5A (0.68) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4986260 | 0.81 | PDE5A (0.68) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL4996010 | 0.81 | PDE5A (0.83) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7162084 | 0.80 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7164781 | 0.79 | PDE5A (0.71) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7159439 | 0.79 | PDE5A (0.68) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002020489-A2 | QUINOLINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-14 | — | — | WO | disclosed |