Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1687115 | 0.87 | EPHX2 (0.52) | EPHX2KMT2AMDM2IDO1 | |
| SCHEMBL15137239 | 0.86 | MDM2 (0.46) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL27810168 | 0.86 | EPHX2 (0.60) | EPHX2KMT2AMDM2IDO1 | |
| SCHEMBL7394109 | 0.85 | CA12 (0.46) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL7395805 | 0.84 | CA12 (0.47) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL17207791 | 0.84 | MDM2 (0.45) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL6757497 | 0.84 | CA12 (0.45) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL6626053 | 0.84 | CA12 (0.45) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL15142312 | 0.84 | MDM2 (0.51) | KMT2AMDM2 | |
| SCHEMBL15136706 | 0.84 | MDM2 (0.47) | CA12CA1CA2CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |