Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.69 |
| ▸ | PDE5A | O76074 | 17/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400203 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7399392 | 0.82 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7397039 | 0.79 | PDE5A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8058416 | 0.77 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7400585 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7451032 | 0.72 | PDE5A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7390028 | 0.72 | PDE4A (0.92) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7392224 | 0.72 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9350631 | 0.70 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7436549 | 0.70 | PDE5A (0.79) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | claimed |
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5409934-A | Antiallergens | BEECHAM GROUP P.L.C. (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0563168-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011260-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-07-09 | — | — | WO | disclosed |