Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739562 | 0.86 | KDM4E (0.61) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL741008 | 0.84 | KDM4E (0.60) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL741494 | 0.82 | KDM4E (0.65) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL739594 | 0.81 | KDM4E (0.57) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL3210765 | 0.80 | GAA (0.56) | MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL739110 | 0.80 | KDM4E (0.67) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL738867 | 0.80 | KDM4E (0.55) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL742062 | 0.80 | KDM4E (0.55) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL742611 | 0.77 | KDM4E (0.56) | MAPTKDM4EPOLBGRIN2BSMN1; SMN2 | |
| SCHEMBL13853671 | 0.76 | POLB (0.62) | MAPTKDM4EPOLBSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |