Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SNCA | P37840 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CTRC | Q99895 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397358 | 1.00 | PDGFRB (0.57) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL7405700 | 1.00 | PDGFRB (0.57) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL7403613 | 0.92 | KMT2A (0.67) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL7403610 | 0.92 | KMT2A (0.67) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL6392297 | 0.86 | DYRK1A (0.55) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL6405982 | 0.86 | DYRK1A (0.55) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5478491 | 0.78 | PDGFRB (0.62) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5478494 | 0.78 | PDGFRB (0.62) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5469417 | 0.76 | KDR (0.73) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5469409 | 0.76 | KDR (0.73) | PDGFRBPLK4PLK1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730579-B1 | SUBSTITUTED INDOLES AS PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-0730579-A1 | SUBSTITUTED INDOLES AS PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5502072-A | INHIBITORS OF PHOSPHODIESTERASE FOT TREATMENT OF AIDS, ASTHMA, RHEUMATOID ARTHRITIS, BRONCHITIS, PSORIASIS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1995014667-A1 | SUBSTITUTED INDOLES AS PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER INC. (US) | 1995-06-01 | — | — | WO | disclosed |