Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Inamrinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 2/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.73 |
| ▸ | INCENP | Q9NQS7 | 9/20 | 0.73 |
| ▸ | TTK | P33981 | 8/20 | 0.73 |
| ▸ | AURKA | O14965 | 6/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | THRB | P10828 | 2/20 | 0.73 |
| ▸ | CASP1 | P29466 | 2/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Inamrinone SCHEMBL44012 | 0.85 | AURKB (1.00) | AURKBINCENPTTKAURKAMAPT | |
| Inamrinone SCHEMBL11449946 | 0.82 | AURKB (0.79) | AURKBINCENPTTKAURKAMAPT | |
| Inamrinone SCHEMBL11467035 | 0.81 | AURKB (0.84) | AURKBINCENPTTKAURKAMAPT | |
| Inamrinone SCHEMBL11447555 | 0.81 | AURKB (0.84) | AURKBINCENPTTKAURKAMAPT | |
| Inamrinone SCHEMBL1648759 | 0.80 | AURKB (0.71) | AURKBINCENPTTKAURKAMAPT | |
| Inamrinone SCHEMBL8627851 | 0.75 | AURKB (0.77) | AURKBINCENPTTKAURKAMAPT | |
| SCHEMBL1392973 | 0.72 | AURKB (1.00) | AURKBINCENPTTKAURKAMAPT | |
| SCHEMBL11163292 | 0.72 | TTK (0.58) | AURKBINCENPTTKAURKAMAPT | |
| SCHEMBL8853769 | 0.71 | CCNC (0.64) | AURKBINCENPTTKAURKAMAPT | |
| SCHEMBL11457740 | 0.70 | ITK (0.64) | AURKBINCENPTTKAURKAITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 325 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021116487-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF NIEMANN-PICK C DISEASE | SOM INNOVATION BIOTECH, S.A. (ES) | 2021-06-17 | — | — | WO | claimed |
| WO-2008116165-A9 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY INC (US) | 2009-06-11 | — | — | WO | claimed |
| WO-2008116165-A2 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| US-20080066741-A1 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | HUNTER, CHARLES ERIC | 2008-03-20 | — | — | US | claimed |
| US-5944020-A | Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery | CYPROS PHARMACEUTICAL CORP. (US) | 1999-08-31 | — | — | US | claimed |
| US-12291797-B2 | Fibronectin type III domain based scaffold compositions, methods and uses | JANSSEN BIOTECH, INC. (US) | 2025-05-06 | — | — | US | disclosed |
| CN-119285648-A | Insect repellent aza-benzothiophenes and aza-benzofuran compounds | 勃林格殷格翰动物保健有限公司 | 2025-01-10 | — | — | CN | disclosed |
| US-12161716-B2 | Anti-IL-23 antibodies, compositions, methods and uses | JANSSEN BIOTECH, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-12129293-B2 | Medical device for administering anti-IL-23 antibodies | JANSSEN BIOTECH, INC. (US) | 2024-10-29 | — | — | US | disclosed |
| CN-113825543-B | Insect repellent aza-benzothiophenes and aza-benzofuran compounds | 勃林格殷格翰动物保健有限公司 | 2024-09-06 | — | — | CN | disclosed |
| US-12065488-B2 | Anti-IL-6 antibody | JANSSEN BIOTECH, INC. (US) | 2024-08-20 | — | — | US | disclosed |
| CN-112996788-B | Anthelmintic heterocyclic compounds | 勃林格殷格翰动物保健美国公司 | 2024-07-16 | — | — | CN | disclosed |
| US-20030170223-A1 | Pulmonary vasodilator surfactant compositions and method of use | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-09-11 | — | — | US | disclosed |
| WO-2001015705-A1 | USE OF FRUCTOSE-1,6-DIPHOSPHATE AS AN INOTROPE DRUG FOR CARDIOPULMONARY BYPASS SURGERY | CYPROS PHARMACEUTICAL CORPORATION (US) | 2001-03-08 | — | — | WO | disclosed |
| US-5944020-A | Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery | CYPROS PHARMACEUTICAL CORP. (US) | 1999-08-31 | — | — | US | disclosed |
| US-5944020-A | Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery | CYPROS PHARMACEUTICAL CORP. (US) | 1999-08-31 | — | — | US | disclosed |
| CN-1195981-A | Inverse Fluorocarbon Emulsion Compositions for Drug Delivery | ALLIANCE PHARMA (US) | 1998-10-14 | — | — | CN | disclosed |
| EP-0833608-A2 | REVERSE FLUOROCARBON EMULSION COMPOSITIONS FOR DRUG DELIVERY | ALLIANCE PHARMACEUTICAL CORPORATION (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040057-A2 | REVERSE FLUOROCARBON EMULSION COMPOSITIONS FOR DRUG DELIVERY | ALLIANCE PHARMACEUTICAL CORP. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |