Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 8/20 | 0.59 |
| ▸ | MMP9 | P14780 | 7/20 | 0.56 |
| ▸ | MMP8 | P22894 | 7/20 | 0.56 |
| ▸ | MMP2 | P08253 | 4/20 | 0.56 |
| ▸ | EDNRA | P25101 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 3/20 | 0.55 |
| ▸ | MMP3 | P08254 | 3/20 | 0.55 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.54 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | MMP15 | P51511 | 1/20 | 0.54 |
| ▸ | MMP16 | P51512 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.54 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.54 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397525 | 1.00 | ECE1 (0.59) | ECE1MMP9MMP8MMP2EDNRA | |
| SCHEMBL7391591 | 1.00 | ECE1 (0.59) | ECE1MMP9MMP8MMP2EDNRA | |
| SCHEMBL7404624 | 0.91 | ACE (0.64) | ECE1EDNRAKMT2AL3MBTL1ACE | |
| SCHEMBL7404621 | 0.91 | ACE (0.64) | ECE1EDNRAKMT2AL3MBTL1ACE | |
| SCHEMBL7402345 | 0.90 | EDNRA (0.64) | ECE1MMP9MMP8MMP2EDNRA | |
| SCHEMBL7402343 | 0.90 | EDNRA (0.64) | ECE1MMP9MMP8MMP2EDNRA | |
| SCHEMBL30053232 | 0.89 | ACE (0.59) | ECE1MMP9MMP8EDNRAMAGI3 | |
| SCHEMBL7446375 | 0.88 | ACE (0.54) | ECE1EDNRAMAGI3KMT2AL3MBTL1 | |
| SCHEMBL7394085 | 0.88 | ACE (0.54) | ECE1EDNRAMAGI3KMT2AL3MBTL1 | |
| SCHEMBL7394083 | 0.88 | ACE (0.54) | ECE1EDNRAMAGI3KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5504070-A | ADMINISTERING OLIGOPEPTIDES, PHOSPHONATES AND MODIFIED AMINO ACIDS AS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1996-04-02 | — | — | US | disclosed |
| WO-1993011154-A1 | INHIBITORS OF THE CONVERSION OF BIG ENDOTHELIN TO ENDOTHELIN | BERLEX LABORATORIES, INC. (US) | 1993-06-10 | — | — | WO | disclosed |