Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | KIT | P10721 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741609 | 0.93 | AURKA (0.52) | AURKAABL1BCRNPC1RAB9A | |
| SCHEMBL740292 | 0.91 | AURKA (0.55) | AURKAABL1BCRNPC1RAB9A | |
| SCHEMBL738866 | 0.89 | AURKA (0.53) | AURKAABL1BCRFLT3NPC1 | |
| SCHEMBL741311 | 0.89 | AURKA (0.53) | AURKAABL1BCRFLT3NPC1 | |
| SCHEMBL740809 | 0.88 | AURKA (0.52) | AURKAABL1BCRFGFR1FGFR2 | |
| SCHEMBL740599 | 0.87 | AURKA (0.49) | AURKAABL1BCRFLT3NPC1 | |
| SCHEMBL1779927 | 0.87 | RXFP1 (0.49) | AURKAABL1BCRNPC1RAB9A | |
| SCHEMBL741926 | 0.87 | AURKA (0.52) | AURKAABL1BCRFLT3KIT | |
| SCHEMBL740260 | 0.86 | AURKA (0.47) | AURKAABL1BCRFLT3KIT | |
| SCHEMBL739853 | 0.86 | AURKA (0.51) | AURKAABL1BCRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |