Sugi Predict

Sugi Predict / Compounds / Pomalidomide

Pomalidomide

Pomalidomide

SCHEMBL7399087

Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2.Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O.Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O.Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O.Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CRBNCUL4ADDB1RBX1

The experimentally established mechanism targets of Pomalidomide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CRBN known ✓ Q96SW2 19/20 0.62
▸ DDB1 known ✓ Q16531 8/20 0.62
▸ IKZF3 Q9UKT9 4/20 0.62
▸ TNF P01375 2/20 0.62
▸ IL1B P01584 2/20 0.62
▸ IKZF1 Q13422 2/20 0.62
▸ BRD4 O60885 1/20 0.62
▸ TBXA2R P21731 1/20 0.59
▸ ALDH1A1 P00352 1/20 0.46
▸ CHRM2 P08172 1/20 0.46
▸ OPRM1 P35372 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ TSHR P16473 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ CSNK1A1 P48729 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pomalidomide SCHEMBL6468105 0.91 CRBN (0.75) CRBNDDB1IKZF3TNFIL1B
Pomalidomide SCHEMBL29287817 0.86 CRBN (0.83) CRBNDDB1IKZF3TNFIL1B
Lenalidomide SCHEMBL28086517 0.84 CRBN (0.89) CRBNDDB1IKZF3TNFIL1B
SCHEMBL20234431 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL29440001 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL501873 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL501751 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Lenalidomide SCHEMBL10192650 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Lenalidomide SCHEMBL868339 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Lenalidomide SCHEMBL10192663 0.79 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242082-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS, RESTENOSIS AND RELATED DISORDERS CELGENE CORPORATION (US) 2002-09-25 — — EP disclosed
WO-2001043743-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS, RESTENOSIS AND RELATED DISORDERS CELGENE CORP. (US) 2001-06-21 — — WO disclosed