Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 3/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18288854 | 0.89 | PDE4A (0.84) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL25280295 | 0.88 | MIF (0.78) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL30457212 | 0.84 | MIF (0.71) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL25237352 | 0.84 | MIF (0.71) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL18279371 | 0.82 | USP2 (0.76) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL14329797 | 0.82 | MIF (0.69) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL17010387 | 0.81 | USP2 (0.78) | MIFMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL22861383 | 0.81 | MIF (1.00) | MIFCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12556064 | 0.81 | MIF (1.00) | MIFCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17010357 | 0.80 | TSHR (0.78) | MIFMAPTKDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114367-A | SUCH AS 3-(3-CYCLOPENTYLOXY-4-METHOXY)PHENYL-2-ISOXAZOLINE-5-HYDROXAMIC ACID; TREATING SEPSIS, SEPTIC SHOCK, INFLAMMATORY BOWEL DISEASE, TUBERCULOSIS, GRAFT VERSUS HOST DISEASE OR CACHEXIA ASSOCIATED WITH AIDS OR CANCER IN A MAMMAL | PFIZER INC (US) | 2000-09-05 | — | — | US | disclosed |
| US-5869511-A | Isoxazoline compounds as inhibitors of TNF release | PFIZER INC. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0749428-B1 | ISOXAZOLINE COMPOUNDS AS INHIBITORS OF TNF RELEASE | PFIZER (US) | 1998-07-29 | — | — | EP | disclosed |
| US-5716967-A | SELECTIVE INHIBITOR OF PHOSPHODIESTERASE TYPE 4, USEFUL IN TREATMENT OF ASTHMA, ARTHRITIS, BRONCHITIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, PSORIASIS, ALLERGIC RHINITIS, DERMATITIS OR SHOCK | PFIZER INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0730588-B1 | ISOXAZOLINE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| EP-0749428-A1 | ISOXAZOLINE COMPOUNDS AS INHIBITORS OF TNF RELEASE | PFIZER INC. (US) | 1996-12-27 | — | — | EP | disclosed |
| EP-0730588-A1 | ISOXAZOLINE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995024398-A1 | ISOXAZOLINE COMPOUNDS AS INHIBITORS OF TNF RELEASE | PFIZER INC. (US) | 1995-09-14 | — | — | WO | disclosed |
| WO-1995014681-A1 | ISOXAZOLINE COMPOUNDS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1995-06-01 | — | — | WO | disclosed |