Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.64 |
| ▸ | CA2 | P00918 | 6/20 | 0.64 |
| ▸ | ACHE | P22303 | 6/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9136687 | 0.95 | CA1 (0.64) | CA1CA2ACHEESR2EPHX2 | |
| SCHEMBL5677299 | 0.95 | CA1 (0.64) | CA1CA2ACHEESR2EPHX2 | |
| SCHEMBL5722246 | 0.95 | CA1 (0.64) | CA1CA2ACHEESR2EPHX2 | |
| SCHEMBL390212 | 0.89 | EPHX2 (0.51) | CA1CA2ACHEESR2EPHX2 | |
| SCHEMBL13262741 | 0.87 | CA1 (0.48) | CA1CA2ACHEEPHX2DRD2 | |
| SCHEMBL13263584 | 0.86 | CA1 (0.47) | CA1CA2ACHEEPHX2DRD2 | |
| SCHEMBL4119861 | 0.86 | CA1 (0.47) | CA1CA2ACHEEPHX2DRD2 | |
| SCHEMBL4101120 | 0.86 | CA1 (0.47) | CA1CA2ACHEEPHX2DRD2 | |
| SCHEMBL17478343 | 0.86 | CA1 (0.47) | CA1CA2ACHEEPHX2DRD2 | |
| SCHEMBL1338041 | 0.86 | CA1 (0.47) | CA1CA2ACHEEPHX2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117910-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0799189-A4 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-17 | — | — | EP | disclosed |
| EP-0799189-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996018602-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | disclosed |