Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537996 | 0.85 | EPHX2 (0.41) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL20674800 | 0.76 | EPHX2 (0.40) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL397490 | 0.75 | CYP2D6 (0.40) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL396125 | 0.75 | CYP2D6 (0.40) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL396124 | 0.75 | CYP2D6 (0.40) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL31226873 | 0.75 | EPHX2 (0.44) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL17222818 | 0.74 | EPHX2 (0.40) | CYP2D6EPHX2CA1CA2MEN1 | |
| SCHEMBL1184772 | 0.74 | MAPT (0.41) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL2180265 | 0.74 | MAPT (0.41) | CYP2D6EPHX2CA1CA2CA7 | |
| SCHEMBL17208366 | 0.73 | CAPN1 (0.46) | CYP2D6EPHX2CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833638-A1 | USE OF IMIDAZO 1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000074-A1 | USE OF IMIDAZO[1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |