Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369624 | 0.84 | KMT2A (0.57) | MAPK8KMT2AALDH1A1 | |
| SCHEMBL7677512 | 0.83 | KMT2A (0.53) | MAPK8KMT2AALDH1A1RAB9APDE4A | |
| SCHEMBL7368289 | 0.82 | KMT2A (0.52) | MAPK8KMT2AALDH1A1RAB9APOLB | |
| SCHEMBL7367823 | 0.81 | MAPK8 (0.83) | MAPK8KMT2AALDH1A1 | |
| SCHEMBL7368595 | 0.81 | KMT2A (0.50) | MAPK8KMT2AALDH1A1RAB9APDE4A | |
| SCHEMBL7405328 | 0.80 | MAPK8 (0.55) | MAPK8KMT2AALDH1A1RAB9APDE4A | |
| SCHEMBL7368614 | 0.80 | KMT2A (0.49) | KMT2AALDH1A1RAB9APDE4APDE4B | |
| SCHEMBL7400057 | 0.80 | KMT2A (0.49) | MAPK8KMT2APDE4APDE4BPDE4C | |
| SCHEMBL29125555 | 0.78 | KMT2A (0.60) | KMT2AALDH1A1RAB9APDE4APDE4B | |
| SCHEMBL29719568 | 0.78 | KMT2A (0.60) | KMT2AALDH1A1RAB9APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |