Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740891 | 1.00 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL741343 | 0.91 | CNR2 (0.45) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL741256 | 0.91 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL741848 | 0.91 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL741847 | 0.91 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL741342 | 0.91 | CNR2 (0.45) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL741257 | 0.91 | KCNH2 (0.45) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL738833 | 0.89 | HRH1 (0.49) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL738834 | 0.89 | HRH1 (0.49) | KCNH2HRH1CYP2D6CHRM1DPP4 | |
| SCHEMBL739481 | 0.88 | CNR2 (0.48) | KCNH2HRH1CYP2D6CHRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |