Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 2/20 | 0.56 |
| ▸ | RXRB | P28702 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10636593 | 0.98 | NPC1 (0.71) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL16689961 | 0.92 | KMT2A (0.67) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL1129093 | 0.87 | MEN1 (0.77) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL2704247 | 0.87 | KMT2A (0.71) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL2842512 | 0.87 | KMT2A (0.71) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL11703832 | 0.87 | KMT2A (0.74) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL11777793 | 0.87 | KMT2A (0.74) | NPC1SMN1; SMN2RAB9APOLBMAPT | |
| SCHEMBL11682986 | 0.86 | NPC1 (0.57) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL27881866 | 0.86 | MAPT (0.60) | NPC1SMN1; SMN2RAB9APOLBCA1 | |
| SCHEMBL16704815 | 0.86 | MAPT (0.60) | NPC1SMN1; SMN2RAB9APOLBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639195-B1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-05-26 | — | — | EP | disclosed |
| US-5587373-A | ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-12-24 | — | — | US | disclosed |
| EP-0639195-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-02-22 | — | — | EP | disclosed |
| WO-1994020504-A1 | 2-ACYLOXYCEPHEM DERIVATIVES AS ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-09-15 | — | — | WO | disclosed |