Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738959 | 1.00 | POLB (0.58) | POLBKDM4ESMYD3HTR2BMAPK1 | |
| SCHEMBL739172 | 0.91 | POLB (0.56) | POLBKDM4EHTR2BMAPK1PARP1 | |
| SCHEMBL738241 | 0.89 | POLB (0.56) | POLBKDM4EHTR2BMAPK1PARP1 | |
| SCHEMBL742129 | 0.88 | POLB (0.55) | POLBKDM4EHTR2BMAPK1PARP1 | |
| SCHEMBL740722 | 0.88 | POLB (0.60) | POLBKDM4EHTR2BMAPK1CYP1A2 | |
| SCHEMBL740999 | 0.88 | POLB (0.57) | POLBKDM4EHTR2BMAPK1CYP1A2 | |
| SCHEMBL740792 | 0.86 | HTR2B (0.54) | POLBKDM4EHTR2BMAPK1USP30 | |
| SCHEMBL738586 | 0.86 | POLB (0.55) | POLBKDM4EHTR2BMAPK1CYP1A2 | |
| SCHEMBL763405 | 0.84 | POLB (0.53) | POLBKDM4EHTR2BMAPK1CYP1A2 | |
| SCHEMBL741246 | 0.84 | POLB (0.53) | POLBKDM4EHTR2BMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |