Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 9/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.78 |
| ▸ | MEN1 | O00255 | 8/20 | 0.78 |
| ▸ | GFER | P55789 | 2/20 | 0.74 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.74 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.74 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | MMP3 | P08254 | 2/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.61 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
| ▸ | NSD2 | O96028 | 1/20 | 0.61 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145580 | 1.00 | POLB (0.78) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7145492 | 0.94 | POLB (0.81) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7145495 | 0.94 | POLB (0.81) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7147356 | 0.92 | PTPN1 (0.73) | POLBKMT2AMEN1GFERPTPN1 | |
| SCHEMBL7149394 | 0.91 | POLB (0.73) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7149398 | 0.91 | POLB (0.73) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7144808 | 0.91 | MEN1 (0.65) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7398219 | 0.91 | MEN1 (0.65) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7144366 | 0.91 | MEN1 (0.65) | POLBKMT2AMEN1GFERPLA2G1B | |
| SCHEMBL7144369 | 0.91 | MEN1 (0.65) | POLBKMT2AMEN1GFERPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189894-A1 | THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001057006-A1 | THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-09 | — | — | WO | disclosed |