Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399903 | 0.87 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7392666 | 0.86 | MEN1 (0.59) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7399357 | 0.85 | MAPT (0.64) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7399024 | 0.78 | MAPT (0.60) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7396145 | 0.77 | MEN1 (0.85) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL6995439 | 0.77 | MEN1 (1.00) | MAPTMEN1KMT2AKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL10552818 | 0.76 | MEN1 (0.98) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL8796596 | 0.75 | MEN1 (0.64) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL5416306 | 0.75 | MAPT (0.71) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL5416313 | 0.75 | MAPT (0.71) | MAPTMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565557-A1 | 1-(4-ACYLAMINOPHENYL)-7,8-METHYLENEDIOXY-5H-2,3-BENZO-DIAZEPINE DERIVATIVES AND ACID ADDITION SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | GYOGYSZERKUTATO INTEZET K.V. (HU) | 1993-10-20 | — | — | EP | disclosed |
| WO-1992011262-A1 | 1-(4-ACYLAMINOPHENYL)-7,8-METHYLENEDIOXY-5H-2,3-BENZO-DIAZEPINE DERIVATIVES AND ACID ADDITION SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | GYÓGYSZERKUTATÓ INTÉZET K.V. (HU) | 1992-07-09 | — | — | WO | disclosed |