Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445430 | 0.78 | ADORA1 (0.50) | ADORA2AADORA1ADORA2BCCNA2CDK2 | |
| SCHEMBL6441743 | 0.77 | ADORA1 (0.56) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL6440638 | 0.77 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL5046621 | 0.76 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BCCNA2CDK2 | |
| SCHEMBL5046844 | 0.75 | ADORA1 (0.60) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL5037058 | 0.75 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BCCNA2CDK2 | |
| SCHEMBL6449356 | 0.75 | ADORA2A (0.54) | ADORA2AADORA1ADORA2BCCNA2CDK2 | |
| SCHEMBL6441656 | 0.75 | ADORA1 (0.49) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL5036930 | 0.74 | ADORA2A (0.59) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 | |
| SCHEMBL6441085 | 0.73 | ADORA2A (0.58) | ADORA2AADORA1ADORA2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261327-A2 | ADENOSINE RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062233-A2 | ADENOSINE RECEPTOR MODULATORS | F. HOFFMANN LA ROCHE AG (CH) | 2001-08-30 | — | — | WO | disclosed |