Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.43 |
| ▸ | HPGD | P15428 | 10/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6442423 | 0.82 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL5036673 | 0.81 | ADORA2A (0.61) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL6441631 | 0.79 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL6444055 | 0.78 | KDM4E (0.61) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL5036966 | 0.78 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL23162564 | 0.76 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL7149984 | 0.75 | ADORA2A (0.59) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL6441055 | 0.75 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL6445453 | 0.74 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BALDH1A1KDM4E | |
| SCHEMBL6446015 | 0.72 | ADORA2A (0.61) | ADORA2AADORA1ADORA2BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261327-A2 | ADENOSINE RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062233-A2 | ADENOSINE RECEPTOR MODULATORS | F. HOFFMANN LA ROCHE AG (CH) | 2001-08-30 | — | — | WO | disclosed |