Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.54 |
| ▸ | CCKAR | P32238 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | GHSR | Q92847 | 1/20 | 0.54 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 11/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404403 | 0.93 | UGT1A1 (0.64) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7405607 | 0.92 | UGT1A1 (0.65) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7403141 | 0.91 | UGT1A1 (0.65) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7546023 | 0.89 | MLNR (0.61) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7539884 | 0.86 | PTPN1 (0.51) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7547786 | 0.86 | MLNR (0.45) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7547783 | 0.86 | MLNR (0.45) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL6179 | 0.84 | UGT1A1 (0.77) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7492730 | 0.83 | PSEN1 (0.55) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL7492736 | 0.83 | PSEN1 (0.55) | MLNRNR1I2SLCO2B1ABCB11ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876336-B1 | AZAHEXANE DERIVATIVES AS SUBSTRATE ISOSTERS OF RETROVIRAL ASPARATE PROTEASES | NOVARTIS AG (CH) | 2002-06-05 | — | — | EP | disclosed |
| US-6225345-B1 | FOR THERAPY OF ACQUIRED IMMUNODEFICIENCY SYNDROME | NOVARTIS AG (CH) | 2001-05-01 | — | — | US | disclosed |
| EP-0876336-A1 | AZAHEXANE DERIVATIVES AS SUBSTRATE ISOSTERS OF RETROVIRAL ASPARATE PROTEASES | Novartis AG (CH) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019055-A1 | AZAHEXANE DERIVATIVES AS SUBSTRATE ISOSTERS OF RETROVIRAL ASPARATE PROTEASES | NOVARTIS AG (CH) | 1997-05-29 | — | — | WO | disclosed |