Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2840650 | 0.88 | PDE10A (0.63) | PDE10AMCHR1PARP1 | |
| SCHEMBL18668570 | 0.81 | PDE10A (0.63) | PDE10AMCHR1TLR8 | |
| SCHEMBL16151253 | 0.80 | PDE10A (0.62) | PDE10AMCHR1TLR8 | |
| SCHEMBL10063391 | 0.80 | MCHR1 (0.68) | PDE10AMCHR1PARP1 | |
| SCHEMBL18682211 | 0.79 | PDE10A (0.68) | PDE10AMCHR1 | |
| SCHEMBL4389390 | 0.77 | PDE10A (0.70) | PDE10AMCHR1 | |
| SCHEMBL4388489 | 0.77 | PDE10A (0.79) | PDE10AMCHR1 | |
| SCHEMBL7453345 | 0.74 | PDE10A (0.61) | PDE10AMCHR1 | |
| SCHEMBL3277356 | 0.74 | PDE10A (0.61) | PDE10AMCHR1 | |
| SCHEMBL27811623 | 0.74 | PDE10A (0.53) | PDE10AMCHR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |