Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.82 |
| ▸ | PDE4A | P27815 | 20/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497555 | 0.91 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7399332 | 0.90 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400136 | 0.82 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8070054 | 0.81 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7394935 | 0.81 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7395907 | 0.78 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400203 | 0.78 | PDE4A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400052 | 0.78 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7397313 | 0.77 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7395737 | 0.74 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | claimed |
| EP-0563168-B1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-5409934-A | Antiallergens | BEECHAM GROUP P.L.C. (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0563168-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011260-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-07-09 | — | — | WO | disclosed |