Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 1.00 |
| ▸ | PDE4A | P27815 | 20/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 20/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986186 | 0.83 | PDE5A (0.71) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7397313 | 0.81 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7395737 | 0.78 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13111716 | 0.77 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7599163 | 0.76 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25235156 | 0.75 | PDE5A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25222680 | 0.74 | PDE5A (0.59) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7392696 | 0.74 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7394935 | 0.74 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400136 | 0.73 | PDE5A (1.00) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550570-A1 | XANTHINE DERIVATIVES | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | claimed |
| WO-1992005175-A1 | XANTHINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | claimed |
| WO-1993023401-A1 | 8-SUBSTITUTED ANTHINES AS PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1993-11-25 | — | — | WO | disclosed |