Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 9/20 | 0.76 |
| ▸ | PDE4A | P27815 | 12/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.74 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14269350 | 0.91 | TNF (0.64) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7444069 | 0.89 | TNF (0.81) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7431167 | 0.89 | TNF (0.73) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4861191 | 0.88 | TNF (0.76) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL825484 | 0.87 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7432606 | 0.87 | TNF (0.77) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7434917 | 0.86 | TNF (0.72) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1264906 | 0.86 | TNF (0.72) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637197 | 0.86 | PDE4A (0.79) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5905008 | 0.85 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065778-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL DISEASES WITH PDE4 MODULATORS | Celgene Corporation (US) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015069711-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL DISEASES WITH PDE4 MODULATORS | CELGENE CORPORATION (US) | 2015-05-14 | — | — | WO | disclosed |
| US-7329761-B2 | Substituted imides | CELGENE CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329761-B2 | Substituted imides | CELGENE CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
| EP-0706521-A1 | NOVEL IMIDES | CELGENE CORPORATION (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001348-A2 | IMIDES AS INHIBITORS OF TNP ALPHA | CELGENE CORPORATION (US) | 1995-01-12 | — | — | WO | disclosed |