Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 4/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401381 | 0.93 | PARP1 (0.37) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7398506 | 0.93 | PARP1 (0.37) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7444384 | 0.89 | PARP1 (0.40) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7398183 | 0.89 | KDM4E (0.35) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7404566 | 0.89 | TRIM24 (0.39) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7451608 | 0.89 | KDM4E (0.36) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7444419 | 0.88 | KDM4E (0.41) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7396533 | 0.88 | KDM4E (0.41) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7400236 | 0.87 | TRIM24 (0.39) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL7444379 | 0.86 | PARP1 (0.39) | PARP1HSD17B1HSD17B2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169181-B1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY | 2001-01-02 | — | — | US | disclosed |
| US-5852195-A | Pyranone compounds useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |