Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398487 | 0.81 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400689 | 0.78 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7401440 | 0.78 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7376573 | 0.75 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7407078 | 0.71 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7400362 | 0.69 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21965200 | 0.67 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21504328 | 0.67 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21504047 | 0.66 | F10 (0.62) | — | |
| SCHEMBL7376577 | 0.65 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707585-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1996-04-24 | — | — | EP | claimed |
| WO-1995001980-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1995-01-19 | — | — | WO | claimed |
| EP-0707585-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001980-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES | PFIZER INC. (US) | 1995-01-19 | — | — | WO | disclosed |