Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409009 | 0.79 | F2 (0.43) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6957150 | 0.72 | F2 (0.75) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7527900 | 0.72 | F2 (0.42) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7449943 | 0.72 | F2 (0.53) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6963877 | 0.71 | F2 (0.47) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7643508 | 0.71 | F2 (0.84) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6957416 | 0.69 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7405320 | 0.68 | F2 (0.44) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8293370 | 0.68 | F2 (0.67) | F2PRSS1 | |
| SCHEMBL5855071 | 0.68 | F2 (0.68) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002064211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
| EP-1189618-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-1189618-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1189899-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000074682-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-2000075134-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-12-14 | — | — | WO | disclosed |